Search results for "Grignard reagent"
showing 5 items of 5 documents
New Insights into the Classic Chiral Grignard Reagent (1R,2S,5R)-Menthylmagnesium Chloride
2006
A molecular electron density theory study of the Grignard reagent‐mediated regioselective direct synthesis of 1,5‐disubstituted‐1,2,3‐triazoles
2020
A Nonconventional Approach toward Multihydroxy Functional Polystyrenes Relying on a Simple Grignard Reagent
2020
Capitalizing on the inertness of styrene toward Grignard reagents, 4-vinylphenylmagnesium bromide was utilized for the rapid and convenient preparation of the protected monomer 2,2-dimethyl-4-(4-vi...
Iron‐Catalyzed Cross‐Couplings in the Synthesis of Pharmaceuticals: In Pursuit of Sustainability
2018
The scarcity of precious metals has led to the development of sustainable strategies for metal-catalyzed cross-coupling reactions. The establishment of new catalytic methods using iron is attractive owing to the low cost, abundance, ready availability, and very low toxicity of iron. In the last few years, sustainable methods for iron-catalyzed cross-couplings have entered the critical area of pharmaceutical research. Most notably, iron is one of the very few metals that have been successfully field-tested as highly effective base-metal catalysts in practical, kilogram-scale industrial cross-couplings. In this Minireview, we critically discuss the strategic benefits of using iron catalysts a…
Über tetraaryl-methan-analoga in der gruppe 14
1994
Abstract The title compounds have been synthesized by Grignard reactions or pyrolysis of diplumbanes respectively. The crystal structures of m -Tol 4 Pb and Ph 4 Pb (redetermination) have been determined. All eight compounds (Ph/Tol) 4 (Sn/Pb) are S 4 symmetric and contracted along this unique axis. The 13 C-NMR chemical shifts and the couplings 1 J ( 119 Sn/ 207 Pb 13 C) as well depend additively upon the methyl substituents. The ratios 1 K ( 207 Pb 13 C): 1 K ( 119 Sn 13 C) of the reduced coupling constants are all near to 1.61; a comparison with values from the literature for alkyl, alkenyl and alkinyl substituents is given. The ratio δ( 207 Pb):δ( 119 Sn) results in 2.28. IR (700 dow…